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And the first went, and poured out his vial upon the earth; and there fell a noisome and grievous sore upon the men which had the mark of the beast, and upon them which worshipped his image. (Revelation 16:2)
The first bowl judgment was cast out onto the earth, and great and repulsive smelling boils broke out on everyone who had taken the mark and worshiped his image. These boils will not only be big and smelly, they will be very painful. They might even be cancerous.